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学术写作:紫杉醇+阿霉素PEG-PLGA共聚物纳米粒

学术写作:紫杉醇+阿霉素PEG-PLGA共聚物纳米粒

有关抗肿瘤的局限性所示单一使用的化疗药物。为了消除毒性的药物,紫杉醇和阿霉素的混合物被用于降低毒性的药物用于治疗肿瘤。因此,提出了两个或两个以上的治疗药物的混合物与指示每种药物的衰减。交付的化疗药物是药物的航空公司提供的援助的胶束,无机纳米粒子和脂质体。的核心壳纳米粒子是双重乳化的两亲性共聚物甲氧基聚(乙二醇)聚(lactide-co-glycolide)或mPEG-PLGA。这有助于创建一个优势为起始的制造过程,可以提高双乳化的过程。纳米粒子是似乎无法提供亲水阿霉素和亲水性紫杉醇。

学术写作:紫杉醇+阿霉素PEG-PLGA共聚物纳米粒

因此,装载的药物进行为了拥有一个更好的多分散性,同时也表明控制粒度分布的性质。co-delivery的人们被抑制肿瘤细胞以更有效的方式比阿霉素和税收保持相同的浓度。

学术写作:紫杉醇+阿霉素PEG-PLGA共聚物纳米粒

The limitations regarding the antitumor are indicated by the single use of the chemotherapeutic drugs. For the purpose of removing the toxicity amount of the drugs, the mixture of the Paclitaxel and the Doxorubicin is being used for decreasing the toxicity of the drugs used for the treatment of the tumors. Therefore, the mixture of two or more therapeutic drugs was proposed with indicating the decrement of each drug. The delivery of the chemotherapeutic drug is being provided by the aid of the drug carriers which are the micelles, inorganic nanoparticles and the liposomes. The core shell of the nanoparticles is doubly emulsified from an amphiphilic copolymer Methoxy poly (ethylene glycol)-poly (lactide-co-glycolide) or the mPEG-PLGA. This aids in creating an advantage for initiation of the fabrication process that can be improved by the process of double emulsion. The nanoparticles are seemed to be not able to deliver the hydrophilic doxorubicin and the hydrophilic paclitaxel.

学术写作:紫杉醇+阿霉素PEG-PLGA共聚物纳米粒

Therefore, the loading of the drugs is undertaken for the purpose of possessing a better polydispersity, and it also indicates controlled nature of the size distribution. The co-delivery of the nanocarriers are suppressed the tumor cells in a more efficient way than the DOX and the TAX with keeping the same concentrations.

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